RS Test

Solvents such as butane, carbon dioxide, and methanol are utilized during the manufacturing process for concentrates to extract the active ingredients in order to produce a resinous, waxy product often referred to as “shatter”. Most concentrates on the market use at least one solvent, whereas others may use multiple.  An issue develops when concentrates are not prepared properly, leaving high levels of solvents in the concentrate, which patients can end up absorbing. CB Labs uses headspace gas chromatography to test for the 24 most commonly found residual solvents including n-Butane, ether, and ethyl acetate to insure all products fall under the “tolerable daily intake” (TDI) set by the International Program on Chemical Safety (IPCS).


Classification of Residual Solvents by Risk Assessment were evaluated for their possible risk to human health and placed into one of three classes as follow:

Class 1 Residual Solvents: Solvents to be Avoided

-known human carcinogens

-strongly suspected human carcinogens

-environmental hazards

Class 2 Residual Solvents: Solvents to be Limited

-nongenotoxic animal carcinogens or possible causative agents of other irreversible toxicity, such as neurotoxicity or teratogenicity.

-solvents suspected of other significant but reversible toxicities

Class 3 Residual Solvents: Solvents with Low Toxic Potential

-solvents with low toxic potential to humans; no health-based exposure limit is needed